To assess circadian rhythm development & congenital cardiovascular disease risk, blood pressure (BP), heart rate (HR) & salivary aldosterone will be monitored for 48 hours after birth on 330 newborns. At 48 hours after birth, circulating aldosterone, TSH &DHEA-S & an echocardiogram will be determined. Parents & other accessible family members will contribute a 48-hours BP & HR profile with a fully ambulatory BP monitor or using specially-designed minimal sampling schemes that do not interfere with daily activities yet allow assessment of BP & HR dynamics, with a room-restricted monitor. A questionnaire will inquire notably about a family history of high BP & diabetes. All infants will be individually tracked, at equivalent or similar to 1.5-year intervals to provide up to 4 profiles (210 infants) between equivalent or similar to 0.5 and equivalent or similar to 4.5 years of age, for a 48-h BP, HR & salivary aldosterone profile, a blood aldosterone, TSH & DHEA-S & an echocardiogram. Chronobiologic analyses will 1) provide reference standards for trend-adjusted means & dynamic cardiovascular features including a chronobiologic index to recognize, at birth, the risk of developing a high BP later in life; 2) quantify age trends; 3) show relations among different (physiologic or imaging) cardiovascular & endocrine variables; 4) indicate the cost-effective neonatal predictor at birth of the follow-up BP & HR means & dynamic characteristics; & 5) compare, by the criterion of BP tracking, the relative merits of an anamnestic or quantitative (familial measurement-based) family history, the chronobiologic & conventional endpoints from familial BP & HP monitoring & the neonatal chronobiologic predictors of cardiovascular disease risk. Cluster analysis should answer the question whether a dynamic neonatal index classifies risk better than the best quantitative family history or BP profile. If so, a neonatal index would gauge the effect of intervention on the pregnant woman & underlie indications for individualized dietary intervention on the newborn.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040650-03
Application #
3357916
Study Section
Special Emphasis Panel (SRC (HB))
Project Start
1988-04-01
Project End
1991-06-30
Budget Start
1990-04-01
Budget End
1991-06-30
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Halberg, Franz; Cornelissen, Germaine; Wall, Dan et al. (2002) Engineering and governmental challenge: 7-day/24-hour chronobiologic blood pressure and heart rate screening: Part I. Biomed Instrum Technol 36:89-122
Halberg, Franz; Cornelissen, Germaine; Wall, Dan et al. (2002) Engineering and governmental challenge: 7-day/24-hour chronobiologic blood pressure and heart rate screening: Part II. Biomed Instrum Technol 36:183-97
Halgberg, F; Cornelissen, G; Watanabe, Y et al. (2001) Near 10-year and longer periods modulate circadians: intersecting anti-aging and chronoastrobiological research. J Gerontol A Biol Sci Med Sci 56:M304-24
Cornelissen, G; Engebretson, M; Johnson, D et al. (2001) The week, inherited in neonatal human twins, found also in geomagnetic pulsations in isolated Antarctica. Biomed Pharmacother 55 Suppl 1:32s-50s
Schaffer, E M; Cornelissen, G; Rhodus, N et al. (2001) Blood pressure outcomes of dental patients screened chronobiologically: a seven-year follow-up. J Am Dent Assoc 132:891-9
Katinas, G S; Halberg, F; Cornelissen, G et al. (2001) About 8- and approximately 84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma. Peptides 22:647-59
Stoynev, A G; Penev, P D; Peneva, A V et al. (1999) Blood pressure and heart rate rhythmicity: differential effects of late pregnancy. Physiol Behav 66:269-75
Cornelissen, G; Gubin, D; Halberg, F et al. (1999) Chronomedical aspects of oncology and geriatrics. In Vivo 13:77-82
Halberg, F; Cornelissen, G; Schwartzkopff, O et al. (1999) Spin-offs from blood pressure and heart rate studies for health care and space research. In Vivo 13:67-76
Blank, M; Denisova, O; Cornelissen, G et al. (1999) Enhanced circasemiseptan (about 3.5-day) variation in the heart rate of cancer patients? Anticancer Res 19:853-5

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