Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040875-02
Application #
3358161
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-07-01
Project End
1993-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203
Patston, P A; Qi, M; Schifferli, J A et al. (1995) The effect of cleavage by a Crotalus atrox alpha-proteinase fraction on the properties of C1-inhibitor. Toxicon 33:53-61
Kourteva, Y; Schapira, M; Patston, P A (1995) The effect of sex and age on antithrombin biosynthesis in the rat. Thromb Res 78:521-9
Patston, P A; Gettins, P G; Schapira, M (1994) The mechanism by which serpins inhibit thrombin and other serine proteinases. Ann N Y Acad Sci 714:13-20
Gettins, P; Patston, P A; Schapira, M (1993) The role of conformational change in serpin structure and function. Bioessays 15:461-7
Patston, P A; Medcalf, R L; Kourteva, Y et al. (1993) C1-inhibitor-serine proteinase complexes and the biosynthesis of C1-inhibitor by Hep G2 and U 937 cells. Blood 82:3371-9
Gettins, P; Patston, P A; Schapira, M (1992) Structure and mechanism of action of serpins. Hematol Oncol Clin North Am 6:1393-408
Patston, P A; Gettins, P; Beechem, J et al. (1991) Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate. Biochemistry 30:8876-82
Skriver, K; Wikoff, W R; Patston, P A et al. (1991) Substrate properties of C1 inhibitor Ma (alanine 434----glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status. J Biol Chem 266:9216-21
Patston, P A; Roodi, N; Schifferli, J A et al. (1990) Reactivity of alpha 1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement, and fibrinolytic systems. J Biol Chem 265:10786-91