This is a resubmission of proposal originally submitted for an NHLBI announcement (KW0715040). Sleep apnea is characterized by repetitive cessation of respiration during sleep, with consequent decreases in blood oxygen saturation, repetitive arousals, daytime somnolence, and complex cardiorespiratory disturbances. There is growing recognition that sleep apnea is a frequent cause of hypertension, cardiorespiratory failure premature death. We have shown that 24% of elderly have at least 5 apneas per hour of sleep, but the prevalence of sleep apnea among American adults under age 65 is unknown. We now propose 1) to determine the prevalence of sleep apnea among both sexes age 40 to 64; 2) to examine the longitudinal course of sleep apnea; and, 3) to examine associations of apneas, oxygen desaturations, snoring, high blood pressure, and other biomedical correlates. A structured random sample will be selected by random digit telephone dialing. Subjects will be studied in their homes. Some will followed yearly during the project. Each volunteer will give a brief sleep history and medical review, including blood pressure measurement, the National Interview Survey, And Quality of Well-being Scale. Blood oxygen saturation, pulse rate, snoring, and sleep duration will be recorded for 3 nights. State-of-the-art computerized pulse oximeters and microprocessor- based activity/light monitors will be used. Subjects found to have the most severe sleep respiratory disturbances will undergo laboratory polysomnograms to add descriptive data and to validate the survey methodology. The prevalence of respiratory disturbances in sleep will be analyzed as a function of age and sex. Associations with several aspects of morbidity will be determined. The longitudinal course of respiratory disturbances in sleep will be examined.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
Project #
Application #
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Ando, Katsuhisa; Kripke, Daniel F; Ancoli-Israel, Sonia (2002) Delayed and advanced sleep phase symptoms. Isr J Psychiatry Relat Sci 39:11-8
Rex, K M; Kripke, D F; Klauber, M R et al. (2001) Sleep-disordered breathing in middle-aged adults predicts no significantly higher rates of traffic violations. Chest 119:1623-4
Jean-Louis, G; Kripke, D F; Ancoli-Israel, S et al. (2000) Circadian sleep, illumination, and activity patterns in women: influences of aging and time reference. Physiol Behav 68:347-52
Jean-Louis, G; Zizi, F; von Gizycki, H et al. (1999) Actigraphic assessment of sleep in insomnia: application of the Actigraph Data Analysis Software (ADAS). Physiol Behav 65:659-63
Jean-Louis, G; Mendlowicz, M V; Von Gizycki, H et al. (1999) Assessment of physical activity and sleep by actigraphy: examination of gender differences. J Womens Health Gend Based Med 8:1113-7
Jean-Louis, G; von Gizycki, H; Zizi, F (1999) Predictors of subjective sleepiness induced by melatonin administration. J Psychosom Res 47:355-8
Jean-Louis, G; von Gizycki, H; Zizi, F et al. (1998) Mood states and sleepiness in college students: influences of age, sex, habitual sleep, and substance use. Percept Mot Skills 87:507-12
Kripke, D F; Klauber, M R; Wingard, D L et al. (1998) Mortality hazard associated with prescription hypnotics. Biol Psychiatry 43:687-93
Rex, K M; Kripke, D F; Cole, R J et al. (1997) Nocturnal light effects on menstrual cycle length. J Altern Complement Med 3:387-90
Kripke, D F; Ancoli-Israel, S; Klauber, M R et al. (1997) Prevalence of sleep-disordered breathing in ages 40-64 years: a population-based survey. Sleep 20:65-76

Showing the most recent 10 out of 13 publications