Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL041644-04
Application #
2220116
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1990-07-01
Project End
1993-06-30
Budget Start
1992-09-01
Budget End
1993-06-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Sen, N; Wu, A M; Spitzer, A R et al. (1997) Activation of protein kinase C by 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II cells. Biochem Pharmacol 53:1307-13
Wadsworth, S; Wu, A M; Spitzer, A et al. (1996) Protein kinase C in intracellular pH regulation in alveolar type II cells. Am J Physiol 271:L106-13
Chander, A; Sen, N; Wu, A M et al. (1996) Methylamine decreases trafficking and packaging of newly synthesized phosphatidylcholine in lamellar bodies in alveolar type II cells. Biochem J 318 ( Pt 1):271-8
Chander, A; Sen, N; Wu, A M et al. (1995) Protein kinase C in ATP regulation of lung surfactant secretion in type II cells. Am J Physiol 268:L108-16
Sen, N; Grunstein, M M; Chander, A (1994) Stimulation of lung surfactant secretion by endothelin-1 from rat alveolar type II cells. Am J Physiol 266:L255-62
Sen, N; Chander, A (1994) Alkalosis- and ATP-induced increases in the diacyglycerol pool in alveolar type II cells are derived from phosphatidylcholine and phosphatidylinositol. Biochem J 298 Pt 3:681-7
Chander, A; Sen, N (1993) Inhibition of phosphatidylcholine secretion by stilbene disulfonates in alveolar type II cells. Biochem Pharmacol 45:1905-12
Chander, A (1992) Dicyclohexylcarbodiimide and vanadate sensitive ATPase of lung lamellar bodies. Biochim Biophys Acta 1123:198-206
Chander, A; Wu, R D (1991) In vitro fusion of lung lamellar bodies and plasma membrane is augmented by lung synexin. Biochim Biophys Acta 1086:157-66