The current project involves two applications (a supplement and a competitive renewal). The purpose of the supplement is to increase the phase out budget during years 08 and 09 to continued follow-up which will go through two months of year. Previously, the applicants have assessed brain structure via MRI (one year); brain function via neurologic examination, and EEG (preoperatively, one-week postoperatively, and at one and four years); and development (at one and four years). There are three overall aims to this project: 1) To compare the effects of the two intraoperative support methods with respect to developmental and neurologic status at age eight years. Developmental status will be measured by the Weschsler Individual Achievement Test (primary outcome) and by the presence of learning disabilities and performance in specific neuropsychologic domains (secondary outcomes). Neurologic status will be determined by neurological exam (primary outcome) and by specific types of dysfunction (e.g. motor problems); (2) To compare the academic and intellectual performance of the cohort at age eight years to population norms and to characterize specific patterns of relative strengths and weaknesses; and (3) To utilize the longitudinal data available on this cohort to identify correlates of the children's eight-year outcomes, as well as their developmental trajectories between ages one and eight.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041786-13
Application #
6343514
Study Section
Special Emphasis Panel (ZHL1-CCT-H (F1))
Program Officer
Pearson, Gail D
Project Start
1988-12-01
Project End
2002-12-31
Budget Start
2001-01-01
Budget End
2002-12-31
Support Year
13
Fiscal Year
2001
Total Cost
$75,022
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Watson, Christopher G; Asaro, Lisa A; Wypij, David et al. (2016) Altered Gray Matter in Adolescents with d-Transposition of the Great Arteries. J Pediatr 169:36-43.e1
Cassidy, Adam R; White, Matthew T; DeMaso, David R et al. (2015) Executive Function in Children and Adolescents with Critical Cyanotic Congenital Heart Disease. J Int Neuropsychol Soc 21:34-49
Bellinger, David C; Newburger, Jane W; Wypij, David et al. (2009) Behaviour at eight years in children with surgically corrected transposition: The Boston Circulatory Arrest Trial. Cardiol Young 19:86-97
Bellinger, David C (2008) Are children with congenital cardiac malformations at increased risk of deficits in social cognition? Cardiol Young 18:3-9
de Ferranti, Sarah; Shapiro, David; Markowitz, Robert et al. (2007) Nonfasting low-density lipoprotein testing: utility for cholesterol screening in pediatric primary care. Clin Pediatr (Phila) 46:441-5
McGrath, Ellen; Wypij, David; Rappaport, Leonard A et al. (2004) Prediction of IQ and achievement at age 8 years from neurodevelopmental status at age 1 year in children with D-transposition of the great arteries. Pediatrics 114:e572-6
Bartlett, Jodi M; Wypij, David; Bellinger, David C et al. (2004) Effect of prenatal diagnosis on outcomes in D-transposition of the great arteries. Pediatrics 113:e335-40
Cottrell, Serena M; Morris, Kevin P; Davies, Paul et al. (2004) Early postoperative body temperature and developmental outcome after open heart surgery in infants. Ann Thorac Surg 77:66-71; discussion 71
de Ferranti, Sarah; Gauvreau, Kimberlee; Hickey, Paul R et al. (2004) Intraoperative hyperglycemia during infant cardiac surgery is not associated with adverse neurodevelopmental outcomes at 1, 4, and 8 years. Anesthesiology 100:1345-52
Wypij, David; Newburger, Jane W; Rappaport, Leonard A et al. (2003) The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 126:1397-403

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