Abstract

The Medical College of Pennsylvania (MCP) and the Riverside Research Institute (RRI) will conduct a collaborative investigation of ultrasonic tissue characterization (UTC) features of thrombi. UTC features will be correlated with gross anatomic and microscopic properties and with clinical findings and outcomes. UTC methodology established at RRI will be developed further and applied to digitized rf echo signals from arterial and venous thrombi. RRI scattering theory will be refined and expanded for application to UTC of thrombi. Animal models will be developed and studies will be performed at MCP to evaluate the UTC features associated with thrombi having morphological features of red- cell fibrin mesh, dense fibrin-platelet regions, and loose fibrin mesh. These studies will be conducted in animals in vivo and studied over a time course to permit formulation of UTC features associated with type and age of thrombi. The results of the animal investigation will be applied in a clinical study of patients having lower-extremity, deep- vein thrombosis and carotid-artery thrombosis associated with atheromatous plaques. These clinical studies will help to establish UTC criteria for classification and staging of thrombosis and for monitoring treatment. A data base will be established and statistical analyses will be performed to correlate UTC features with microscopy and clinical findings, to develop discriminant functions for thrombus characterization, and to assess the clinical relevance of UTC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041874-03
Application #
3359665
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1989-07-01
Project End
1994-06-30
Budget Start
1991-07-20
Budget End
1994-06-30
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129

  Publications

O'Brien, Sean P; Sigel, Bernard; Justin, Jeffery et al. (2004) Carotid plaque spaces relate to symptoms and ultrasound scattering. Ultrasound Med Biol 30:611-6
Lee, D J; Sigel, B; Swami, V K et al. (1998) Determination of carotid plaque risk by ultrasonic tissue characterization. Ultrasound Med Biol 24:1291-9
Noritomi, T; Sigel, B; Gahtan, V et al. (1997) In vivo detection of carotid plaque thrombus by ultrasonic tissue characterization. J Ultrasound Med 16:107-11
Noritomi, T; Sigel, B; Swami, V et al. (1997) Carotid plaque typing by multiple-parameter ultrasonic tissue characterization. Ultrasound Med Biol 23:643-50
Kitamura, H; Sigel, B; Machi, J et al. (1995) Roles of hematocrit and fibrinogen in red cell aggregation determined by ultrasonic scattering properties. Ultrasound Med Biol 21:827-32
Kolecki, R V; Sigel, B; Justin, J et al. (1995) Determining the acuteness and stability of deep venous thrombosis by ultrasonic tissue characterization. J Vasc Surg 21:976-84
Sigel, B; Swami, V; Can, A et al. (1994) Intimal hyperplasia producing thrombus organization in an experimental venous thrombosis model. J Vasc Surg 19:350-60
Machi, J; Sigel, B; Roberts, A B et al. (1994) Oversaturation of color may obscure small intraluminal partial occlusions in color Doppler imaging. J Ultrasound Med 13:735-41;quiz 821-2
Hosokawa, T; Sigel, B; Machi, J et al. (1994) Experimental assessment of spectrum analysis of ultrasonic echoes as a method for estimating scatterer properties. Ultrasound Med Biol 20:463-70
Parsons, R E; Sigel, B; Feleppa, E J et al. (1993) Ultrasonic tissue characterization of experimental venous intimal hyperplasia. Ultrasound Med Biol 19:299-308

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