Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041910-07
Application #
2220198
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1990-12-01
Project End
1996-12-31
Budget Start
1993-07-01
Budget End
1996-12-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Ehlers, C L; Somes, C; Cloutier, D (1998) Are some of the effects of ethanol mediated through NPY? Psychopharmacology (Berl) 139:136-44
Ehlers, C L; Somes, C; Lopez, A et al. (1997) Electrophysiological actions of neuropeptide Y and its analogs: new measures for anxiolytic therapy? Neuropsychopharmacology 17:34-43
Kirby, D A; Britton, K T; Aubert, M L et al. (1997) Identification of high-potency neuropeptide Y analogues through systematic lactamization. J Med Chem 40:210-5
Ehlers, C L; Somes, C; Seifritz, E et al. (1997) CRF/NPY interactions: a potential role in sleep dysregulation in depression and anxiety. Depress Anxiety 6:1-9
Jiang, G; Miller, C; Koerber, S C et al. (1997) Betidamino acid scan of the GnRH antagonist acyline. J Med Chem 40:3739-48
Pierroz, D D; Catzeflis, C; Aebi, A C et al. (1996) Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 137:3-12
Kirby, D A; Boublik, J H; Rivier, J E (1993) Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions. J Med Chem 36:3802-8
Kirby, D A; Koerber, S C; Craig, A G et al. (1993) Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogues. J Med Chem 36:385-93
Reymond, M T; Delmas, L; Koerber, S C et al. (1992) Truncated, branched, and/or cyclic analogues of neuropeptide Y: importance of the pancreatic peptide fold in the design of specific Y2 receptor ligands. J Med Chem 35:3653-9
Feinstein, R D; Boublik, J H; Kirby, D et al. (1992) Structural requirements for neuropeptide Y18-36-evoked hypotension: a systematic study. J Med Chem 35:2836-43

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