Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL042050-02
Application #
3360017
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1988-12-01
Project End
1993-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Silverman, H S; Wei, S; Haigney, M C et al. (1997) Myocyte adaptation to chronic hypoxia and development of tolerance to subsequent acute severe hypoxia. Circ Res 80:699-707
Stern, M D (1996) ""Adaptive"" behavior of ligand-gated ion channels: constraints by thermodynamics. Biophys J 70:2100-9
Cave, A C; Adrian, S; Apstein, C S et al. (1996) A model of anoxic preconditioning in the isolated rat cardiac myocyte. Importance of adenosine and insulin. Basic Res Cardiol 91:210-8
Silverman, H S; Di Lisa, F; Hui, R C et al. (1994) Regulation of intracellular free Mg2+ and contraction in single adult mammalian cardiac myocytes. Am J Physiol 266:C222-33
Haigney, M C; Lakatta, E G; Stern, M D et al. (1994) Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation 90:391-9
Silverman, H S (1993) Mitochondrial free calcium regulation in hypoxia and reoxygenation: relation to cellular injury. Basic Res Cardiol 88:483-94
Miyata, H; Lakatta, E G; Stern, M D et al. (1992) Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia. Circ Res 71:605-13
Silverman, H S; Stern, M D; Lakatta, E G (1992) Contrasting effects of anoxia and graded hypoxia on single cardiac myocyte function. Am J Cardiovasc Pathol 4:256-64
Ziegelstein, R C; Zweier, J L; Mellits, E D et al. (1992) Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects. Circ Res 70:804-11
Haigney, M C; Miyata, H; Lakatta, E G et al. (1992) Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange. Circ Res 71:547-57

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