Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL042057-07
Application #
2220268
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1988-12-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Virginia
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Kinter, M; Wolstenholme, J T; Thornhill, B A et al. (1999) Unilateral ureteral obstruction impairs renal antioxidant enzyme activation during sodium depletion. Kidney Int 55:1327-34
Brown, K E; Kinter, M T; Oberley, T D et al. (1998) Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload. Free Radic Biol Med 24:545-55
Kinter, M; Roberts, R J (1996) Glutathione consumption and glutathione peroxidase inactivation in fibroblast cell lines by 4-hydroxy-2-nonenal. Free Radic Biol Med 21:457-62
Kinter, M; Spitz, D R; Roberts, R J (1996) Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity. J Nutr 126:2952-9
Grace, J M; MacDonald, T L; Roberts, R J et al. (1996) Determination of site-specific modifications of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal using matrix assisted laser desorption time-of-flight mass spectrometry. Free Radic Res 25:23-9
Spitz, D R; Kinter, M T; Roberts, R J (1995) Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts. J Cell Physiol 165:600-9
Walker, M W; Kinter, M T; Roberts, R J et al. (1995) Nitric oxide-induced cytotoxicity: involvement of cellular resistance to oxidative stress and the role of glutathione in protection. Pediatr Res 37:41-9
Kinter, M; Robinson, C S; Grimminger, L C et al. (1994) Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in Watanabe heritable hyperlipidemic versus New Zealand White rabbits. Biochem Biophys Res Commun 199:671-5
Goligorsky, M S; Morgan, M A; Lyubsky, S et al. (1993) Establishment of a hydrogen peroxide resistant variant of renal tubular epithelial cells: role of calcium-independent phospholipase A2 in cell damage. Arch Biochem Biophys 301:119-28
Spitz, D R; Phillips, J W; Adams, D T et al. (1993) Cellular resistance to oxidative stress is accompanied by resistance to cisplatin: the significance of increased catalase activity and total glutathione in hydrogen peroxide-resistant fibroblasts. J Cell Physiol 156:72-9

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