The long-term objective of this research continue to be to understand (1) the role of hemodynamics in the localization and development of atherosclerosis, and (2) the extent to which local geometric features of arteries, as mediators of the hemodynamic environment of the vessel wall, influence an individual's susceptibility to vascular disease. These objectives are approached by relating the geometric features of coronary arteries obtained from post-mortem angiograms to the histopathology of the vessels. Angiograms are prepared in multiple planes of the left coronary arteries of autopsy hearts gathered locally and from University of Maryland and Louisiana State University. The hearts are prepared under the established Pathobiological Determinants of Atherosclerosis in Youth (PDAY) protocols. The left main coronary artery, the first 5-8 cm of the left anterior descending artery, the proximal circumflex artery, and the proximal portions of their early branches, are removed from the hearts and characterized with respect to wall thickness, structure, and composition, stainable lipid and lesion distribution by image processing of (1) soft x-ray films of entire vessels and (2) selected transverse sections prepared with histological stains of immunocytochemical markers. The soft x-ray imaging and histotechnique will be performed at the University of Illinois at Chicago. The multiplane angiograms are processed, using objective computerized algorithms, to reconstruct the course of the axes of the segments of interest in three-space. A Second set of objective algorithms is then applied to these geometries to obtain quantitative geometric parameters of the segments (e.g., branch angles, branch asymmetry, distances between branch points and other landmarks, and tortuosity). The relation among these parameters, the morphology and pathology of the specimens, and the subjects' risk factor profiles will be examined in detail using appropriate statistical techniques. An understanding of the relation between arterial geometry and the predisposition to atherosclerosis can improve the productivity of epidemiological studies and suggest """"""""geometric risk factors"""""""" that may predict an individuals susceptibility to atherosclerosis at specific sites. The known effects of geometry on local flow fields will be used to draw inferences regarding the role of hemodynamics in relation to human atherogenesis.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
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Diagnostic Radiology Study Section (RNM)
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Ohio State University
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Friedman, Morton H (2002) Variability of 3D arterial geometry and dynamics, and its pathologic implications. Biorheology 39:513-7
Friedman, M H; Ding, Z (1998) Relation between the structural asymmetry of coronary branch vessels and the angle at their origin. J Biomech 31:273-8
Gross, M F; Friedman, M H (1998) Dynamics of coronary artery curvature obtained from biplane cineangiograms. J Biomech 31:479-84
Friedman, M H; Ding, Z (1998) Variability of the planarity of the human aortic bifurcation. Med Eng Phys 20:469-72
Perktold, K; Hofer, M; Rappitsch, G et al. (1998) Validated computation of physiologic flow in a realistic coronary artery branch. J Biomech 31:217-28
Ding, Z; Biggs, T; Seed, W A et al. (1997) Influence of the geometry of the left main coronary artery bifurcation on the distribution of sudanophilia in the daughter vessels. Arterioscler Thromb Vasc Biol 17:1356-60
Friedman, M H; Baker, P B; Ding, Z et al. (1996) Relationship between the geometry and quantitative morphology of the left anterior descending coronary artery. Atherosclerosis 125:183-92
Friedman, M H; Kuban, B D; Schmalbrock, P et al. (1995) Fabrication of vascular replicas from magnetic resonance images. J Biomech Eng 117:364-6
Sun, H; Kuban, B D; Schmalbrock, P et al. (1994) Measurement of the geometric parameters of the aortic bifurcation from magnetic resonance images. Ann Biomed Eng 22:229-39
Brinkman, A M; Baker, P B; Newman, W P et al. (1994) Variability of human coronary artery geometry: an angiographic study of the left anterior descending arteries of 30 autopsy hearts. Ann Biomed Eng 22:34-44

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