Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL042467-05
Application #
2220519
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1990-01-01
Project End
1995-03-31
Budget Start
1994-01-01
Budget End
1995-03-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Knowlton, K U; Rockman, H A; Itani, M et al. (1995) Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest 96:1311-8
Anan, R; Greve, G; Thierfelder, L et al. (1994) Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy. J Clin Invest 93:280-5
MacRae, C A; Watkins, H C; Jarcho, J A et al. (1994) An evaluation of ribonuclease protection assays for the detection of beta-cardiac myosin heavy chain gene mutations. Circulation 89:33-5
Thierfelder, L; Watkins, H; MacRae, C et al. (1994) Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell 77:701-12
Solomon, S D; Wolff, S; Watkins, H et al. (1993) Left ventricular hypertrophy and morphology in familial hypertrophic cardiomyopathy associated with mutations of the beta-myosin heavy chain gene. J Am Coll Cardiol 22:498-505
Watkins, H; MacRae, C; Thierfelder, L et al. (1993) A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3. Nat Genet 3:333-7
Watkins, H; Thierfelder, L; Anan, R et al. (1993) Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy. Am J Hum Genet 53:1180-5
Watkins, H; Thierfelder, L; Hwang, D S et al. (1992) Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations. J Clin Invest 90:1666-71
Watkins, H; Seidman, C E; MacRae, C et al. (1992) Progress in familial hypertrophic cardiomyopathy: molecular genetic analyses in the original family studied by Teare. Br Heart J 67:34-8
Seidman, C E; Seidman, J G (1991) Mutations in cardiac myosin heavy chain genes cause familial hypertrophic cardiomyopathy. Mol Biol Med 8:159-66

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