Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL042607-07
Application #
2220599
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1989-05-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Warner, R L; Lewis, C S; Beltran, L et al. (2001) The role of metalloelastase in immune complex-induced acute lung injury. Am J Pathol 158:2139-44
Warner, R L; Beltran, L; Younkin, E M et al. (2001) Role of stromelysin 1 and gelatinase B in experimental acute lung injury. Am J Respir Cell Mol Biol 24:537-44
Takeuchi, K; del Nido, P J; Poutias, D N et al. (2000) Vesnarinone restores contractility and calcium handling in early endotoxemia. Circulation 102:III365-9
Warner, R L; Bless, N M; Lewis, C S et al. (2000) Time-dependent inhibition of immune complex-induced lung injury by catalase: relationship to alterations in macrophage and neutrophil matrix metalloproteinase elaboration. Free Radic Biol Med 29:16-Aug
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Takeuchi, K; del Nido, P J; Ibrahim, A E et al. (1999) Increased myocardial calcium cycling and reduced myofilament calcium sensitivity in early endotoxemia. Surgery 126:231-8
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Gibbs, D F; Warner, R L; Weiss, S J et al. (1999) Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Am J Respir Cell Mol Biol 20:1136-44
Varani, J; Hirschl, R B; Dame, M et al. (1996) Perfluorocarbon protects lung epithelial cells from neutrophil-mediated injury in an in vitro model of liquid ventilation therapy. Shock 6:339-44
Varani, J; Perone, P; Inman, D R et al. (1995) Human skin in organ culture. Elaboration of proteolytic enzymes in the presence and absence of exogenous growth factors. Am J Pathol 146:210-7

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