Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL044201-03
Application #
2221384
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1993-01-01
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Liao, Y; Yi, T; Hoit, B D et al. (1997) Selective reporter expression in mast cells using a chymase promoter. J Biol Chem 272:2969-76
Sanker, S; Chandrasekharan, U M; Wilk, D et al. (1997) Distinct multisite synergistic interactions determine substrate specificities of human chymase and rat chymase-1 for angiotensin II formation and degradation. J Biol Chem 272:2963-8
Chandrasekharan, U M; Sanker, S; Glynias, M J et al. (1996) Angiotensin II-forming activity in a reconstructed ancestral chymase. Science 271:502-5
Bastos, M; Maeji, N J; Abeles, R H (1995) Inhibitors of human heart chymase based on a peptide library. Proc Natl Acad Sci U S A 92:6738-42
Murakami, M; Karnik, S S; Husain, A (1995) Human prochymase activation. A novel role for heparin in zymogen processing. J Biol Chem 270:2218-23
Hoit, B D; Shao, Y; Kinoshita, A et al. (1995) Effects of angiotensin II generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboon. J Clin Invest 95:1519-27
Liao, Y; Husain, A (1995) The chymase-angiotensin system in humans: biochemistry, molecular biology and potential role in cardiovascular diseases. Can J Cardiol 11 Suppl F:13F-19F
Urata, H; Boehm, K D; Philip, A et al. (1993) Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. J Clin Invest 91:1269-81
Kinoshita, A; Urata, H; Bumpus, F M et al. (1993) Measurement of angiotensin I converting enzyme inhibition in the heart. Circ Res 73:51-60
Urata, H; Karnik, S S; Graham, R M et al. (1993) Dipeptide processing activates recombinant human prochymase. J Biol Chem 268:24318-22