Abstract

This study examines the role of inflammatory factors underlying the physiological and psychological symptoms associated with obstructive sleep apnea. Inflammatory markers (C reactive protein, interleukin-6, tumor necrosing factor alpha) will be examined in blood and urine in 80 patients with obstructive sleep apnea and in 25 normal controls. The study will examine the relationship between inflammatory markers, procoagulant markers, and hallmark signs of sleep apnea such as the respiratory disturbance, intermittent oxygen desaturation, elevated sympathetic nervous system activity as well as depressive symptoms, neuropsychological impairment, and quality of life. The 80 patients with sleep apnea will then be randomized for 3 weeks of treatment to either CPAP or sub-therapeutic CPAP. Treatment effects will be studied in terms of effects on procoagulant markers and on the relationship between inflammatory factors, the respiratory disturbance, intermittent oxygen desaturation, elevated sympathetic nervous system activity as well as depressive symptoms, neuropsychological impairment, and quality of life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL044915-16
Application #
7257790
Study Section
Special Emphasis Panel (ZRG1-PRDP (01))
Program Officer
Jobe, Jared B
Project Start
1991-08-01
Project End
2009-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
16
Fiscal Year
2007
Total Cost
$600,912
Indirect Cost

  Institution

Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Tomfohr, Lianne M; Pung, Meredith A; Dimsdale, Joel E (2016) Mediators of the relationship between race and allostatic load in African and White Americans. Health Psychol 35:322-32
Tomfohr, Lianne M; Edwards, Kate M; Madsen, Joshua W et al. (2015) Social support moderates the relationship between sleep and inflammation in a population at high risk for developing cardiovascular disease. Psychophysiology 52:1689-97
von Känel, Roland (2015) ACUTE MENTAL STRESS AND HEMOSTASIS: WHEN PHYSIOLOGY BECOMES VASCULAR HARM. Thromb Res 135:S52-S55
von Känel, Roland (2015) Acute mental stress and hemostasis: When physiology becomes vascular harm. Thromb Res 135 Suppl 1:S52-5
Euteneuer, Frank; Mills, Paul J; Pung, Meredith A et al. (2014) Neighborhood problems and nocturnal blood pressure dipping. Health Psychol 33:1366-72
Edwards, Kate M; Kamat, Rujvi; Tomfohr, Lianne M et al. (2014) Obstructive sleep apnea and neurocognitive performance: the role of cortisol. Sleep Med 15:27-32
Euteneuer, Frank; Ziegler, Michael G; Mills, Paul J et al. (2014) In vivo ?-adrenergic receptor responsiveness: ethnic differences in the relationship with symptoms of depression and fatigue. Int J Behav Med 21:843-50
von Känel, Roland; Natarajan, Loki; Ancoli-Israel, Sonia et al. (2013) Effect of continuous positive airway pressure on day/night rhythm of prothrombotic markers in obstructive sleep apnea. Sleep Med 14:58-65
Euteneuer, Frank; Mills, Paul J; Rief, Winfried et al. (2012) Association of in vivo ýý-adrenergic receptor sensitivity with inflammatory markers in healthy subjects. Psychosom Med 74:271-7
Tomfohr, Lianne; Pung, Meredith A; Edwards, Kate M et al. (2012) Racial differences in sleep architecture: the role of ethnic discrimination. Biol Psychol 89:34-8

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