The primary objective of this proposal is to complete the data analysis for the Cholesterol Lowering Atherosclerosis Study (CLAS) -- a randomized, placebo controlled, angiographic clinical trial providing information on human atherosclerosis regression/progression in coronary, femoral, and carotid arteries. Two and four year endpoint data have been collected for coronary (panel reading and image processed), femoral (image processed) and carotid arteries (image processed). Risk factor data are available on baseline and on-trial clinical measures, lipids, apolipoproteins and nutrient intake. Unique features of CLAS include: 1) simultaneous angiography and image analysis of carotid, femoral and coronary arteries; 2) the opportunity to observe arterial wall risk factor effects of a wide range of plasma cholesterol levels (185 to 350 mg%) without a confounding influence from smoking; and 3) the opportunity to evaluate dietary effects on atherosclerosis regression/progression in an extensive nutritional database. Statistical evaluation will include both a per-segment analysis (taking into account segment inter-dependence) and a per-patient analysis. These analyses will address an important conceptual problem inherent in vessel image based trials, the issue of the independence of segments/lesions within a patient.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL045005-02
Application #
3363871
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1991-01-01
Project End
1993-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Azen, S P; Mack, W J; Cashin-Hemphill, L et al. (1996) Progression of coronary artery disease predicts clinical coronary events. Long-term follow-up from the Cholesterol Lowering Atherosclerosis Study. Circulation 93:34-41
Hodis, H N; Mack, W J; LaBree, L et al. (1996) Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: a randomized controlled clinical trial. Ann Intern Med 124:548-56
Azen, S P; Qian, D; Mack, W J et al. (1996) Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. Circulation 94:2369-72
Hodis, H N; Mack, W J; LaBree, L et al. (1995) Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 273:1849-54
Shircore, A M; Mack, W J; Selzer, R H et al. (1995) Compensatory vascular changes of remote coronary segments in response to lesion progression as observed by sequential angiography from a controlled clinical trial. Circulation 92:2411-8
Hodis, H N; Mack, W J; Azen, S P et al. (1994) Triglyceride- and cholesterol-rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by quantitative coronary angiography in a controlled trial of lovastatin. Circulation 90:42-9
Alaupovic, P; Hodis, H N; Knight-Gibson, C et al. (1994) Effects of lovastatin on ApoA- and ApoB-containing lipoproteins. Families in a subpopulation of patients participating in the Monitored Atherosclerosis Regression Study (MARS). Arterioscler Thromb 14:1906-13
Selzer, R H; Hodis, H N; Kwong-Fu, H et al. (1994) Evaluation of computerized edge tracking for quantifying intima-media thickness of the common carotid artery from B-mode ultrasound images. Atherosclerosis 111:1-11
Blankenhorn, D H; Selzer, R H; Crawford, D W et al. (1993) Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound. Circulation 88:20-8
Mack, W J; Selzer, R H; Hodis, H N et al. (1993) One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy. Stroke 24:1779-83

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