Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL045287-01S1
Application #
3364264
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1990-09-30
Project End
1993-06-30
Budget Start
1990-09-30
Budget End
1991-06-30
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Rensselaer Polytechnic Institute
Department
Type
Schools of Arts and Sciences
DUNS #
002430742
City
Troy
State
NY
Country
United States
Zip Code
12180

  Publications

Frye, L L; Leonard, D A (1999) Lanosterol analogs: dual-action inhibitors of cholesterol biosynthesis. Crit Rev Biochem Mol Biol 34:123-40
Anderson, J A; Leonard, D A; Cusack, K P et al. (1995) 15-substituted lanosterols: post-transcriptional suppressors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Arch Biochem Biophys 316:190-6
Frye, L L; Cusack, K P; Leonard, D A et al. (1994) Oxolanosterol oximes: dual-action inhibitors of cholesterol biosynthesis. J Lipid Res 35:1333-44
Frye, L L; Cusack, K P; Leonard, D A (1993) 32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis. J Med Chem 36:410-6