Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL045332-06
Application #
2222089
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1990-07-01
Project End
1995-06-30
Budget Start
1994-11-01
Budget End
1995-06-30
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Kwak, Young L; Jones, Keith A; Warner, David O et al. (2006) Prolonged relaxation consistent with persistent soluble guanylyl cyclase activation in canine pulmonary artery following brief treatment with nitric oxide donors. Life Sci 79:2001-9
Lader, A S; Xiao, Y F; Ishikawa, Y et al. (1998) Cardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway. Proc Natl Acad Sci U S A 95:9669-74
Cittadini, A; Stromer, H; Vatner, D E et al. (1997) Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats. Endocrinology 138:5161-9
Vatner, D E; Sato, N; Galper, J B et al. (1996) Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure. Circulation 94:102-7
Eysmann, S B; Gervino, E; Vatner, D E et al. (1996) Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans. J Appl Physiol 80:616-22
Vatner, D E; Sato, N; Ishikawa, Y et al. (1996) Beta-adrenoceptor desensitization during the development of canine pacing-induced heart failure. Clin Exp Pharmacol Physiol 23:688-92
Kacimi, R; Moalic, J M; Aldashev, A et al. (1995) Differential regulation of G protein expression in rat hearts exposed to chronic hypoxia. Am J Physiol 269:H1865-73
Gaudin, C; Ishikawa, Y; Wight, D C et al. (1995) Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest 95:1676-83
Kiuchi, K; Shen, Y T; Vatner, S F et al. (1994) Mechanisms mediating responsiveness to beta-adrenergic stimulation after coronary reperfusion in conscious dogs. Am J Physiol 267:H1578-88
Vatner, D E; Sato, N; Kiuchi, K et al. (1994) Decrease in myocardial ryanodine receptors and altered excitation-contraction coupling early in the development of heart failure. Circulation 90:1423-30

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