The respiratory action of the intercostal muscles will be analyzed. The principles of engineering mechanics yield the relation between muscle force and the change in pleural pressure that the force produces. Data that describe the geometry and motion of the parasternal region of the dog will be obtained to augment existing data on the geometry and motion of dog and human ribs. The distributions of intercostal muscle orientation and mass in dogs and humans will be measured. From these data, the factors that appear in the relation between force and pleural pressure will be evaluated and the potential respiratory action of the intercostal muscle will be calculated. The relation between force and pleural pressure will be demonstrated in a controlled experiment in which known forces will be applied to the rib cage to simulate the action of the intercostals, and limits of the theory imposed by geometrical and mechanical nonlinearities will be determined. A quantitative description of the respiratory mechanics of the intercostal muscles will be obtained.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL045545-01
Application #
3364572
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1991-03-01
Project End
1994-02-28
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Engineering
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455