Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL045554-02S1
Application #
3364591
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1992-02-05
Project End
1995-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Toledo
Department
Type
Schools of Medicine
DUNS #
807418939
City
Toledo
State
OH
Country
United States
Zip Code
43614
Jack-Hays, M G; Xie, Z; Wang, Y et al. (1996) Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta 1279:43-8
Lai, C C; Huang, W H; Klevay, L M et al. (1996) Antioxidant enzyme gene transcription in copper-deficient rat liver. Free Radic Biol Med 21:233-40
Lai, C C; Peng, M; Huang, L et al. (1996) Chronic exposure of neonatal cardiac myocytes to hydrogen peroxide enhances the expression of catalase. J Mol Cell Cardiol 28:1157-63
Xie, Z; Jack-Hays, M; Wang, Y et al. (1995) Different oxidant sensitivities of the alpha 1 and alpha 2 isoforms of Na+/K(+)-ATPase expressed in baculovirus-infected insect cells. Biochem Biophys Res Commun 207:155-9
Sarvazyan, N; Askari, A; Klevay, L M et al. (1995) Role of intracellular SOD in oxidant-induced injury to normal and copper-deficient cardiac myocytes. Am J Physiol 268:H1115-21
Huang, W; Lai, C C; Wang, Y et al. (1995) Altered expressions of cardiac Na/K-ATPase isoforms in copper deficient rats. Cardiovasc Res 29:563-8
Sarvazyan, N A; Askari, A; Huang, W H (1995) Effects of doxorubicin on cardiomyocytes with reduced level of superoxide dismutase. Life Sci 57:1003-10
Peng, M; Huang, L; Xie, Z J et al. (1995) Oxidant-induced activations of nuclear factor-kappa B and activator protein-1 in cardiac myocytes. Cell Mol Biol Res 41:189-97
Lai, C C; Huang, W H; Askari, A et al. (1994) Differential regulation of superoxide dismutase in copper-deficient rat organs. Free Radic Biol Med 16:613-20
Huang, W H; Wang, Y; Askari, A et al. (1994) Different sensitivities of the Na+/K(+)-ATPase isoforms to oxidants. Biochim Biophys Acta 1190:108-14

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