.) It is hypothesized that the cellular and temporal pattern of expression of the GRP receptor is critical in determining the action of the peptide. This will be studied through a program focused on the characterization of the gastrin releasing peptide receptor. Furthermore, antibodies directed against the GRP receptor will be produced and used as highly specific antagonists.
Specific Aims i nclude the following: 1. Development of immunologic and molecular reagents with which to study GRP receptor. 2. Analysis of GRP receptor cDNA sequence and deduction of GRP receptor structure and function. 3. Descriptive studies of GRP receptor expression. 4. Interference of GRP action in lung development using receptor-directed agents.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL045745-04
Application #
2222464
Study Section
Pathology A Study Section (PTHA)
Project Start
1991-01-01
Project End
1995-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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