Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL045880-04
Application #
2222514
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1992-04-17
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Sullivan, R; Koliwad, S K; Kunze, D L (1998) Analysis of a Ca2+-activated K+ channel that mediates hyperpolarization via the thrombin receptor pathway. Am J Physiol 275:C1342-8
Kunze, D L; Sinkins, W G; Vaca, L et al. (1997) Properties of single Drosophila Trpl channels expressed in Sf9 insect cells. Am J Physiol 272:C27-34
Koliwad, S K; Kunze, D L; Elliott, S J (1996) Oxidant stress activates a non-selective cation channel responsible for membrane depolarization in calf vascular endothelial cells. J Physiol 491 ( Pt 1):1-12
Sinkins, W G; Vaca, L; Hu, Y et al. (1996) The COOH-terminal domain of Drosophila TRP channels confers thapsigargin sensitivity. J Biol Chem 271:2955-60
Sullivan, R; Kunze, D L; Kroll, M H (1996) Thrombin receptors activate potassium and chloride channels. Blood 87:648-56
Koliwad, S K; Elliott, S J; Kunze, D L (1996) Oxidized glutathione mediates cation channel activation in calf vascular endothelial cells during oxidant stress. J Physiol 495 ( Pt 1):37-49
Vaca, L; Kunze, D L (1995) IP3-activated Ca2+ channels in the plasma membrane of cultured vascular endothelial cells. Am J Physiol 269:C733-8
Vaca, L; Kunze, D L (1994) Depletion of intracellular Ca2+ stores activates a Ca(2+)-selective channel in vascular endothelium. Am J Physiol 267:C920-5
Vaca, L; Sinkins, W G; Hu, Y et al. (1994) Activation of recombinant trp by thapsigargin in Sf9 insect cells. Am J Physiol 267:C1501-5
Vaca, L; Gurrola, G B; Possani, L D et al. (1993) Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker. J Membr Biol 134:123-9