Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL045931-06A1
Application #
2222556
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1990-09-30
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Kaul, Dhananjay K; Fabry, Mary E (2004) In vivo studies of sickle red blood cells. Microcirculation 11:153-65
Kaul, D K; Liu, X; Nagel, R L (2001) Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature. Blood 98:3128-31
Kaul, D K; Liu, X D; Fabry, M E et al. (2000) Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse. Am J Physiol Heart Circ Physiol 278:H1799-806
Kaul, D K; Tsai, H M; Liu, X D et al. (2000) Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood 95:368-74
Kaul, D K; Liu, X D (1999) Rate of deoxygenation modulates rheologic behavior of sickle red blood cells at a given mean corpuscular hemoglobin concentration. Clin Hemorheol Microcirc 21:125-35
Barabino, G A; Liu, X D; Ewenstein, B M et al. (1999) Anionic polysaccharides inhibit adhesion of sickle erythrocytes to the vascular endothelium and result in improved hemodynamic behavior. Blood 93:1422-9
Kaul, D K; Liu, X D; Nagel, R L et al. (1998) Microvascular hemodynamics and in vivo evidence for the role of intercellular adhesion molecule-1 in the sequestration of infected red blood cells in a mouse model of lethal malaria. Am J Trop Med Hyg 58:240-7
Hirsch, R E; Jelicks, L A; Wittenberg, B A et al. (1997) A first evaluation of the natural high molecular weight polymeric Lumbricus terrestris hemoglobin as an oxygen carrier. Artif Cells Blood Substit Immobil Biotechnol 25:429-44
Kaul, D K; Fabry, M E; Costantini, F et al. (1995) In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest 96:2845-53
Kaul, D K; Chen, D; Zhan, J (1994) Adhesion of sickle cells to vascular endothelium is critically dependent on changes in density and shape of the cells. Blood 83:3006-17

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