Fibrin Alpha Chain Crosslinks as Markers of Fibrinolysis

Sobel, Joan H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL045936-03
• Application #: 3365012
• Study Section: Special Emphasis Panel (SRC (OE))
• Project Start: 1990-09-30
• Project End: 1995-07-31
• Budget Start: 1992-08-01
• Budget End: 1993-07-31
• Support Year: 3
• Fiscal Year: 1992

Institution

• Name: Columbia University (N.Y.)
• Type: Schools of Medicine
• DUNS #: 064931884
• City: New York
• State: NY
• Country: United States
• Zip Code: 10027

Publications

Rudchenko, S; Trakht, I; Sobel, J H (1996) Comparative structural and functional features of the human fibrinogen alpha C domain and the isolated alpha C fragment. Characterization using monoclonal antibodies to defined COOH-terminal A alpha chain regions. J Biol Chem 271:2523-30

Mitkevich, O V; Sobel, J H; Shainoff, J R et al. (1996) Monoclonal antibody directed to a fibrinogen A alpha #529-539 epitope inhibits alpha-chain crosslinking by transglutaminases. Blood Coagul Fibrinolysis 7:85-92

Sobel, J H; Gawinowicz, M A (1996) Identification of the alpha chain lysine donor sites involved in factor XIIIa fibrin cross-linking. J Biol Chem 271:19288-97

Sobel, J H; Trakht, I; Wu, H Q et al. (1995) Alpha-Chain cross-linking in fibrin(ogen) Marburg. Blood 86:989-1000

Sobel, J H; Wu, H Q; Canfield, R E (1994) The development of assays for the detection of fibrin(ogen)olysis based on COOH-terminal A alpha chain epitopes. Blood 84:535-46

Donaldson, D J; Mahan, J T; Amrani, D L et al. (1994) Further studies on the interaction of migrating keratinocytes with fibrinogen. Cell Adhes Commun 2:299-308