Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL045964-04S1
Application #
3365060
Study Section
Special Emphasis Panel (SRC (OA))
Project Start
1990-09-30
Project End
1995-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Kelsen, S G; Anakwe, O O; Aksoy, M O et al. (1997) Chronic effects of catecholamines on the beta 2-adrenoreceptor system in cultured human airway epithelial cells. Am J Physiol 272:L916-24
Penn, R B; Shaver, J R; Zangrilli, J G et al. (1996) Effects of inflammation and acute beta-agonist inhalation on beta 2-AR signaling in human airways. Am J Physiol 271:L601-8
Hosey, M M; Benovic, J L; DebBurman, S K et al. (1995) Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors. Life Sci 56:951-5
Kelsen, S G; Higgins, N C; Zhou, S et al. (1995) Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. Am J Respir Crit Care Med 152:1774-83
Gurevich, V V; Chen, C Y; Kim, C M et al. (1994) Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity. J Biol Chem 269:8721-7
Kelsen, S G; Zhou, S; Anakwe, O et al. (1994) Expression of the beta-adrenergic receptor-adenylylcyclase system in basal and columnar airway epithelial cells. Am J Physiol 267:L456-63
Penn, R B; Kelsen, S G; Benovic, J L (1994) Regulation of beta-agonist- and prostaglandin E2-mediated adenylyl cyclase activity in human airway epithelial cells. Am J Respir Cell Mol Biol 11:496-505
Mardini, I A; Higgins, N C; Zhou, S et al. (1994) Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. Am J Respir Cell Mol Biol 11:287-95
Kunapuli, P; Onorato, J J; Hosey, M M et al. (1994) Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. J Biol Chem 269:1099-105
Kong, G; Penn, R; Benovic, J L (1994) A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor. J Biol Chem 269:13084-7

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