Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL046152-03S1
Application #
2222685
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1991-04-01
Project End
1996-05-31
Budget Start
1993-04-01
Budget End
1996-05-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Memphis
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Memphis
State
TN
Country
United States
Zip Code
38152
Derrick, J M; Taylor, D B; Loudon, R G et al. (1997) The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin alphaIIbbeta3. Biochem J 325 ( Pt 2):309-13
Wang, X; Coons, L B; Taylor, D B et al. (1996) Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. J Biol Chem 271:17785-90
Wang, X; Lessman, C A; Taylor, D B et al. (1995) Fibronectin peptide DRVPHSRNSIT and fibronectin receptor peptide DLYYLMDL arrest gastrulation of Rana pipiens. Experientia 51:1097-102
Taylor, D B; Derrick, J M; Gartner, T K (1994) Antibodies to GPIIb alpha (300-312) inhibit Fg binding, clot retraction, and platelet adhesion to multiple ligands. Proc Soc Exp Biol Med 205:35-43
Gartner, T K; Taylor, D B; Derrick, J (1994) Complementary peptides that interfere with platelet aggregation and adherence. Immunomethods 5:148-57
Gartner, T K; Amrani, D L; Derrick, J M (1994) Characterization of adhesion of non-exogenously stimulated and resting platelets in normal plasma to fibrinogen and its fragments. Blood Coagul Fibrinolysis 5:747-54
Gartner, T K; Amrani, D L; Derrick, J M et al. (1993) Characterization of adhesion of ""resting"" and stimulated platelets to fibrinogen and its fragments. Thromb Res 71:47-60
Taylor, D B; Gartner, T K (1992) A peptide corresponding to GPIIb alpha 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIb/IIIa, inhibits the adhesion of platelets to at least four adhesive ligands. J Biol Chem 267:11729-33
Gartner, T K; Loudon, R; Taylor, D B (1991) The peptides APLHK, EHIPA and GAPL are hydropathically equivalent peptide mimics of a fibrinogen binding domain of glycoprotein IIb/IIIa. Biochem Biophys Res Commun 180:1446-52