Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL046179-04
Application #
2449146
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1993-05-01
Project End
1997-10-31
Budget Start
1997-02-01
Budget End
1997-10-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Emory University
Department
Surgery
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Vinten-Johansen, J; Zhao, Z Q; Nakamura, M et al. (1999) Nitric oxide and the vascular endothelium in myocardial ischemia-reperfusion injury. Ann N Y Acad Sci 874:354-70
Vinten-Johansen, J; Thourani, V H; Ronson, R S et al. (1999) Broad-spectrum cardioprotection with adenosine. Ann Thorac Surg 68:1942-8
Jordan, J E; Zhao, Z Q; Sato, H et al. (1997) Adenosine A2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence. J Pharmacol Exp Ther 280:301-9
Zhao, Z Q; Lefer, D J; Sato, H et al. (1997) Monoclonal antibody to ICAM-1 preserves postischemic blood flow and reduces infarct size after ischemia-reperfusion in rabbit. J Leukoc Biol 62:292-300
Zhao, Z Q; Todd, J C; Sato, H et al. (1997) Adenosine inhibition of neutrophil damage during reperfusion does not involve K(ATP)-channel activation. Am J Physiol 273:H1677-87
Sato, H; Zhao, Z Q; Jordan, J E et al. (1997) Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization. J Thorac Cardiovasc Surg 113:399-409
Sato, H; Jordan, J E; Zhao, Z Q et al. (1997) Gradual reperfusion reduces infarct size and endothelial injury but augments neutrophil accumulation. Ann Thorac Surg 64:1099-107
Sato, H; Zhao, Z Q; Vinten-Johansen, J (1996) L-Arginine inhibits neutrophil adherence and coronary artery dysfunction. Cardiovasc Res 31:63-72
Zhao, Z Q; Sato, H; Williams, M W et al. (1996) Adenosine A2-receptor activation inhibits neutrophil-mediated injury to coronary endothelium. Am J Physiol 271:H1456-64
Sato, H; Zhao, Z Q; McGee, D S et al. (1995) Supplemental L-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury. J Thorac Cardiovasc Surg 110:302-14

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