The interrelation between form and function in the developing cardiovascular system is largely unknown. Experiments with embryonic chick hearts have shown that perturbing ventricular pressure alters the rate of growth without affecting the rate of morphological development. These results suggest a biomechanical basis for growth, but the specific mechanism(s) is not yet known. The long-term goal of this research is to identify the biomechanical factor that regulates growth in the embryonic chick ventricle. Correlating experimental data with results given by a realistic theoretical model will facilitate meeting this goal. Hence, the specific aims of this project are: 1. Develop a series of theoretical models for the embryonic ventricle during the early stages of development from a muscle-wrapped tube into a four-chambered pump. Compute stress, strain, blood flow, and strain- energy density distributions in the ventricular wall using nonlinear shell theory and poroelasticity theory. 2. Measure the geometric and biomechanical properties of the embryonic chick heart by correlating theoretical results with data from material testing protocols. Determine how these properties change with development and perturbed loading conditions. 3. Validate the model by comparing theoretical predictions with measured epicardial wall strains and blood-flow distributions through the wall of the embryonic chick heart. 4. Use the model to study the effects of various material and geometric parameters on stress, strain, blood flow, and strain-energy density distributions in the ventricular wall. 5. Correlate experimental and theoretical results to normal growth patterns from experiments that alter normal cardiac loadings. Identify the biomechanical factor(s) that regulates heart development. Supporting biologic studies of function and growth, the theoretical model will promote and understanding of the biomechanical principles responsible for normal and abnormal cardiac development.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL046367-04
Application #
2222856
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1992-02-01
Project End
1996-09-14
Budget Start
1995-02-01
Budget End
1996-09-14
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Rochester
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Damon, Brooke J; RĂ©mond, Mathieu C; Bigelow, Michael R et al. (2009) Patterns of muscular strain in the embryonic heart wall. Dev Dyn 238:1535-46
Chabert, Steren; Taber, Larry A (2002) Intramyocardial pressure measurements in the stage 18 embryonic chick heart. Am J Physiol Heart Circ Physiol 282:H1248-54
Taber, L A; Chabert, S (2002) Theoretical and experimental study of growth and remodeling in the developing heart. Biomech Model Mechanobiol 1:29-43
Voronov, Dmitry A; Taber, Larry A (2002) Cardiac looping in experimental conditions: effects of extraembryonic forces. Dev Dyn 224:413-21
Taber, L A (2001) Biomechanics of cardiovascular development. Annu Rev Biomed Eng 3:1-25
Taber, L A; Humphrey, J D (2001) Stress-modulated growth, residual stress, and vascular heterogeneity. J Biomech Eng 123:528-35
Taber, L A; Zahalak, G I (2001) Theoretical model for myocardial trabeculation. Dev Dyn 220:226-37
Taber, L A; Ng, S; Quesnel, A M et al. (2001) Investigating Murray's law in the chick embryo. J Biomech 34:121-4
Taber, L A (1998) Mechanical aspects of cardiac development. Prog Biophys Mol Biol 69:237-55
Taber, L A (1998) An optimization principle for vascular radius including the effects of smooth muscle tone. Biophys J 74:109-14

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