Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL046462-02
Application #
2222946
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1995-06-07
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Prabhakar, Nanduri R; Dick, Thomas E; Nanduri, Jayasri et al. (2007) Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol 92:39-44
Prabhakar, Nanduri R (2006) O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters? Exp Physiol 91:17-23
Kim, Dong-Kyu; Summers, Beth A; Prabhakar, Nanduri R et al. (2003) Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body. Adv Exp Med Biol 536:291-6
Kim, D K; Summers, B A; Prabhakar, N R et al. (2001) Neurotransmitter release from the rabbit carotid body: differential effects of hypoxia on substance P and acetylcholine release. Adv Exp Med Biol 499:39-43
Kim, D K; Oh, E K; Summers, B A et al. (2001) Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels. Brain Res 892:359-69
Kumar, G K; Yu, R K; Overholt, J L et al. (2000) Role of substance P in neutral endopeptidase modulation of hypoxic response of the carotid body. Adv Exp Med Biol 475:705-13
Kumar, G K; Kou, Y R; Overholt, J L et al. (2000) Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia. J Appl Physiol 88:195-202
Kumar, G K; Oh, E K; Lee, M S (2000) Interaction between catecholamines and neuropeptides in the carotid body: evidence for dopamine modulation of neutral endopeptidase activity. Adv Exp Med Biol 475:507-15
Haqqi, T M; Anthony, D D; Gupta, S et al. (1999) Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci U S A 96:4524-9
Kumar, G K (1997) Peptidases of the peripheral chemoreceptors: biochemical, immunological, in vitro hydrolytic studies and electron microscopic analysis of neutral endopeptidase-like activity of the carotid body. Brain Res 748:39-50

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