Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL046528-02
Application #
3365649
Study Section
Special Emphasis Panel (SRC (JD))
Project Start
1991-11-01
Project End
1995-05-31
Budget Start
1991-11-01
Budget End
1992-05-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Moritz, T; Dutt, P; Xiao, X et al. (1996) Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments. Blood 88:855-62
Orazi, A; Du, X; Yang, Z et al. (1996) Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. Lab Invest 75:33-42
Yoder, M C; King, B; Hiatt, K et al. (1995) Murine embryonic yolk sac cells promote in vitro proliferation of bone marrow high proliferative potential colony-forming cells. Blood 86:1322-30
Du, X; Williams, D A (1995) Update on development of interleukin-11. Curr Opin Hematol 2:182-8
Miyazawa, K; Williams, D A; Gotoh, A et al. (1995) Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85:641-9
Du, X X; Scott, D; Yang, Z X et al. (1995) Interleukin-11 stimulates multilineage progenitors, but not stem cells, in murine and human long-term marrow cultures. Blood 86:128-34
Du, X X; Doerschuk, C M; Orazi, A et al. (1994) A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy. Blood 83:33-7
Moritz, T; Patel, V P; Williams, D A (1994) Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. J Clin Invest 93:1451-7
Williams, D A; Moritz, T (1994) Genetic manipulation of hematopoietic stem cells in adenosine deaminase deficiency. Adv Exp Med Biol 370:395-400
Majumdar, M K; Feng, L; Medlock, E et al. (1994) Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein. J Biol Chem 269:1237-42

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