Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL046536-03S1
Application #
3365663
Study Section
Special Emphasis Panel (SRC (JD))
Project Start
1991-05-01
Project End
1995-02-28
Budget Start
1993-04-01
Budget End
1994-02-28
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Harrison, D E; Astle, C M (1997) Short- and long-term multilineage repopulating hematopoietic stem cells in late fetal and newborn mice: models for human umbilical cord blood. Blood 90:174-81
Harrison, D E; Zhong, R K; Jordan, C T et al. (1997) Relative to adult marrow, fetal liver repopulates nearly five times more effectively long-term than short-term. Exp Hematol 25:293-7
Zhong, R K; Astle, C M; Harrison, D E (1996) Distinct developmental patterns of short-term and long-term functioning lymphoid and myeloid precursors defined by competitive limiting dilution analysis in vivo. J Immunol 157:138-45
Zhong, R K; Donnenberg, A D; Edison, L et al. (1996) The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin. Int Immunol 8:171-6
Jordan, C T; Astle, C M; Zawadzki, J et al. (1995) Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation. Exp Hematol 23:1011-5
Harrison, D E; Zsebo, K M; Astle, C M (1994) Splenic primitive hematopoietic stem cell (PHSC) activity is enhanced by steel factor because of PHSC proliferation. Blood 83:3146-51
Harrison, D E; Jordan, C T; Zhong, R K et al. (1993) Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol 21:206-19
Harrison, D E; Zhong, R K (1992) The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation. Proc Natl Acad Sci U S A 89:10134-8