Dynamics of Apoe Binding to Lipoproteins and Receptors

Mims, Martha P.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL046860-04
• Application #: 2223252
• Study Section: Metabolism Study Section (MET)
• Project Start: 1993-04-01
• Project End: 1998-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Baylor College of Medicine
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 074615394
• City: Houston
• State: TX
• Country: United States
• Zip Code: 77030

Publications

Salinelli, S; Lo, J Y; Mims, M P et al. (1996) Structure-function relationship of lipoprotein lipase-mediated enhancement of very low density lipoprotein binding and catabolism by the low density lipoprotein receptor. Functional importance of a properly folded surface loop covering the catalytic cente J Biol Chem 271:21906-13

Li, J; Fang, B; Eisensmith, R C et al. (1995) In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene. J Clin Invest 95:768-73

Mims, M P; Darnule, A T; Tovar, R W et al. (1994) A nonexchangeable apolipoprotein E peptide that mediates binding to the low density lipoprotein receptor. J Biol Chem 269:20539-47

Whitson, J S; Mims, M P; Strittmatter, W J et al. (1994) Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. Biochem Biophys Res Commun 199:163-70