Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047072-04
Application #
2223386
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Pieper, G M; Lai, C S (1999) Biological evaluation of the nitric oxide-trapping agent, N-methyl-D-glucamine dithiocarbamate-Fe2+, as a probe of nitric oxide activity released from control and diabetic rat endothelium. Jpn J Pharmacol 80:359-70
Pieper, G M (1999) Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 42:204-13
Pieper, G M; Dondlinger, L A (1998) Antioxidant pyrrolidine dithiocarbamate prevents defective bradykinin-stimulated calcium accumulation and nitric oxide activity following exposure of endothelial cells to elevated glucose concentration. Diabetologia 41:806-12
Cooper, M; Lindholm, P; Pieper, G et al. (1998) Myocardial nuclear factor-kappaB activity and nitric oxide production in rejecting cardiac allografts. Transplantation 66:838-44
Pieper, G M; Adams, M B; Roza, A M (1998) Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus. Surgery 123:89-95
Dembny, K D; Roza, A M; Johnson, C et al. (1998) Heparin interferes with the determination of plasma nitric oxide by inhibition of enzymatic conversion of nitrate to nitrite by nitrate reductase. Clin Chim Acta 275:107-14
Pieper, G M (1998) Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction. Hypertension 31:1047-60
Pieper, G M; Dembny, K; Siebeneich, W (1998) Long-term treatment in vivo with NOX-101, a scavenger of nitric oxide, prevents diabetes-induced endothelial dysfunction. Diabetologia 41:1220-6
Pieper, G M; Siebeneich, W (1998) Oral administration of the antioxidant, N-acetylcysteine, abrogates diabetes-induced endothelial dysfunction. J Cardiovasc Pharmacol 32:101-5
Nakanishi, A L; Roza, A M; Adams, M B et al. (1998) Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate. Free Radic Biol Med 25:201-7

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