Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047391-04
Application #
2223614
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1992-02-20
Project End
1997-01-31
Budget Start
1995-02-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Peters-Golden, M; Brock, T G (2000) Intracellular compartmentalization of leukotriene biosynthesis. Am J Respir Crit Care Med 161:S36-40
Healy, A M; Peters-Golden, M; Yao, J P et al. (1999) Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase. J Biol Chem 274:29812-8
Brock, T G; McNish, R W; Peters-Golden, M (1999) Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J Biol Chem 274:11660-6
Covin, R B; Brock, T G; Bailie, M B et al. (1998) Altered expression and localization of 5-lipoxygenase accompany macrophage differentiation in the lung. Am J Physiol 275:L303-10
Brock, T G; McNish, R W; Peters-Golden, M (1998) Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. Biochem J 329 ( Pt 3):519-25
Brock, T G; McNish, R W; Bailie, M B et al. (1997) Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence. J Biol Chem 272:8276-80
Peters-Golden, M; McNish, R W; Davis, J A et al. (1996) Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages. Am J Physiol 271:L1004-13
Wilborn, J; Bailie, M; Coffey, M et al. (1996) Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 97:1827-36
Coffey, M J; Wheeler, C S; Gross, K B et al. (1996) Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology 114:187-97
Peters-Golden, M; Song, K; Marshall, T et al. (1996) Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis. Biochem J 318 ( Pt 3):797-803

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