Abstract

In the course of our research on blood imaging (as distinguished from flow imaging) we have devised a system for measuring and/or imaging oxygen saturation in vessels. Our initial results using both in vitro and in vivo studies appear very encouraging. Oxygen saturation could well provide the most significant functional MR image. We acquire data with this technique in normal imaging times and with typical spatial resolution. We anticipate a wide range of clinical applications. In addition to optimizing and clinically verifying this technique, we plan to study the same effect to estimate the oxygen level in organs and tissue capillary beds.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047448-02
Application #
3366647
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1992-02-01
Project End
1995-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Engineering
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Chan, F P; Jahr, J S; Driessen, B et al. (2001) Validation of in vivo MR measurement of oxygen saturation after resuscitation with a hemoglobin-based oxygen carrier in a rabbit model. Acad Radiol 8:583-90
Chan, F P; Li, K C; Heiss, S G et al. (1999) A comprehensive approach using MR imaging to diagnose acute segmental mesenteric ischemia in a porcine model. AJR Am J Roentgenol 173:523-9
Li, K C; Dalman, R L; Wright, G A (1999) In vivo flow-independent T2 measurements of superior mesenteric vein blood in diagnosis of chronic mesenteric ischemia: a preliminary evaluation. Acad Radiol 6:530-4
Foltz, W D; Merchant, N; Downar, E et al. (1999) Coronary venous oximetry using MRI. Magn Reson Med 42:837-48
Li, K C; Pelc, L R; Puvvala, S et al. (1998) Mesenteric ischemia due to hemorrhagic shock: MR imaging diagnosis and monitoring in a canine model. Radiology 206:219-25
Heiss, S G; Li, K C (1998) Magnetic resonance angiography of mesenteric arteries. A review. Invest Radiol 33:670-81
Foltz, W D; Stainsby, J A; Wright, G A (1997) T2 accuracy on a whole-body imager. Magn Reson Med 38:759-68
Brittain, J H; Olcott, E W; Szuba, A et al. (1997) Three-dimensional flow-independent peripheral angiography. Magn Reson Med 38:343-54
Li, K C (1997) Magnetic resonance angiography of the visceral arteries: techniques and current applications. Endoscopy 29:496-503
Li, K C; Pelc, L R; Dalman, R L et al. (1997) In vivo magnetic resonance evaluation of blood oxygen saturation in the superior mesenteric vein as a measure of the degree of acute flow reduction in the superior mesenteric artery: findings in a canine model. Acad Radiol 4:21-5

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