Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047804-05
Application #
2223888
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1992-08-13
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1998-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
City
Torrance
State
CA
Country
United States
Zip Code
90502
Ibe, Basil O; Portugal, Ada M; Usha Raj, J (2002) Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. Mol Genet Metab 77:237-48
Raj, Usha; Shimoda, Larissa (2002) Oxygen-dependent signaling in pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol 283:L671-7
Ibe, B O; Raj, J U (2001) Leukotriene metabolism by intrapulmonary vessels of newborn lambs: effect of platelet-activating factor. Exp Lung Res 27:331-48
Ibe, B O; Pham, H H; Kaapa, P et al. (2001) Maturational changes in ovine pulmonary metabolism of platelet-activating factor: implications for postnatal adaptation. Mol Genet Metab 74:385-95
Ibe, B O; Sander, F C; Raj, J U (2000) Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. Am J Physiol Heart Circ Physiol 278:H1168-76
Ibe, B O; Sander, F C; Raj, J U (2000) Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. Mol Genet Metab 69:46-55
Gao, Y; Tolsa, J F; Botello, M et al. (1998) Developmental change in isoproterenol-mediated relaxation of pulmonary veins of fetal and newborn lambs. J Appl Physiol 84:1535-9
Ibe, B O; Hibler, S; Raj, J U (1998) Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb. J Appl Physiol 85:1079-85
Gao, Y; Tolsa, J F; Raj, J U (1998) Heterogeneity in endothelium-derived nitric oxide-mediated relaxation of different sized pulmonary arteries of newborn lambs. Pediatr Res 44:723-9
Gao, Y; Tolsa, J F; Shen, H et al. (1998) Effect of selective phosphodiesterase inhibitors on response of ovine pulmonary arteries to prostaglandin E2. J Appl Physiol 84:13-8

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