Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048455-03
Application #
2224505
Study Section
Special Emphasis Panel (SRC (FR))
Project Start
1992-05-01
Project End
1997-03-31
Budget Start
1994-03-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Zhao, Shuiling; Ghosh, Anindya; Lo, Chao-Sheng et al. (2018) Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice. Endocrinology 159:836-852
Lo, Chao-Sheng; Shi, Yixuan; Chang, Shiao-Ying et al. (2015) Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-?1-induced kidney injury in a mouse model of diabetes. Diabetologia 58:2443-54
Shi, Yixuan; Lo, Chao-Sheng; Padda, Ranjit et al. (2015) Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice. Clin Sci (Lond) 128:649-63
Abdo, Shaaban; Shi, Yixuan; Otoukesh, Abouzar et al. (2014) Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice. Diabetes 63:3483-96
Shi, Yixuan; Lo, Chao-Sheng; Chenier, Isabelle et al. (2013) Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice. Am J Physiol Renal Physiol 304:F1335-46
Abdo, S; Lo, C-S; Chenier, I et al. (2013) Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice. Diabetologia 56:1649-60
Lo, Chao-Sheng; Chang, Shiao-Ying; Chenier, Isabelle et al. (2012) Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice. Diabetes 61:2597-608
Lau, Garnet J; Godin, Nicolas; Maachi, Hasna et al. (2012) Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice. Diabetes 61:474-84
Lo, Chao-Sheng; Liu, Fang; Shi, Yixuan et al. (2012) Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. Am J Physiol Renal Physiol 302:F840-52
Godin, Nicolas; Liu, Fang; Lau, Garnet J et al. (2010) Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice. Kidney Int 77:1086-97

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