Pathogenesis of Chronic Pulmonary Hypertension

Meyrick, Barbara O.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL048536-04
• Application #: 2224607
• Study Section: Lung Biology and Pathology Study Section (LBPA)
• Project Start: 1993-06-01
• Project End: 1997-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Vanderbilt University Medical Center
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 004413456
• City: Nashville
• State: TN
• Country: United States
• Zip Code: 37212

Publications

Fratz, Sohrab; Meyrick, Barbara; Ovadia, Boaz et al. (2004) Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. Am J Physiol Lung Cell Mol Physiol 287:L592-7

Chen, Daohong; Balyakina, Elena V; Lawrence, Mayme et al. (2003) Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 284:L614-21

Balyakina, Elena V; Chen, Daohong; Lawrence, Mayme L et al. (2002) ET-1 receptor gene expression and distribution in L1 and L2 cells from hypertensive sheep pulmonary artery. Am J Physiol Lung Cell Mol Physiol 283:L42-51

Meyrick, B (2001) The pathology of pulmonary artery hypertension. Clin Chest Med 22:393-404, vii

Chazova, I; Robbins, I; Loyd, J et al. (2000) Venous and arterial changes in pulmonary veno-occlusive disease, mitral stenosis and fibrosing mediastinitis. Eur Respir J 15:116-22

Tchekneva, E; Lawrence, M L; Meyrick, B (2000) Cell-specific differences in ET-1 system in adjacent layers of main pulmonary artery. A new source of ET-1. Am J Physiol Lung Cell Mol Physiol 278:L813-21

Slovis, B S; Chazova, I; Loyd, J E et al. (1998) Pulmonary capillary haemangiomatosis coexistence with sinus venosus ASD: morphometric analysis and literature review. Eur Respir J 12:240-4

Tchekneva, E; Quertermous, T; Christman, B W et al. (1998) Regional variability in preproEndothelin-1 gene expression in sheep pulmonary artery and lung during the onset of air-induced chronic pulmonary hypertension. Participation Of arterial smooth muscle cells. J Clin Invest 101:1389-97

Johnson, J E; Perkett, E A; Meyrick, B (1997) Pulmonary veins and bronchial vessels undergo remodeling in sustained pulmonary hypertension induced by continuous air embolization into sheep. Exp Lung Res 23:459-73

Gossage, J R; Perkett, E A; Davidson, J M et al. (1995) Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep. J Appl Physiol 79:1163-72