Novel Organic Reagents for Biomedical Applications

Hosmane, Ramachandra S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL048632-02
• Application #: 2224703
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Project Start: 1994-09-30
• Project End: 1997-08-31
• Budget Start: 1995-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1995

Institution

• Name: University of Maryland Baltimore
• Department: Chemistry
• Type: Schools of Medicine
• DUNS #: 003255213
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21201

Publications

Roach, Timothy A; Macdonald, Victor W; Hosmane, Ramachandra S (2004) A novel site-directed affinity reagent for cross-linking human hemoglobin: bis[2-(4-phosphonooxyphenoxy)carbonylethyl]phosphinic acid. J Med Chem 47:5847-59

Peri, S P; Bhadti, V S; Somerville-Armstrong, K S et al. (1999) Affinity reagents for cross-linking hemoglobin: bis(phenoxycarbonylethyl)phosphinic acid (BPCEP) and bis(3-nitrophenoxycarbonylethyl)phosphinic acid (BNCEP). Hemoglobin 23:1-20

Hosmane, R S; Peri, S P; Bhadti, V S et al. (1998) Bis[2-(4-carboxyphenoxy)carbonylethyl]phosphinic acid (BCCEP): a novel affinity reagent for the beta-cleft modification of human hemoglobin. Bioorg Med Chem 6:767-83

Peri, S P; Bhadti, V S; Hosmane, R S et al. (1997) Bis[2-(4-carboxyphenoxy)carbonylethyl]phosphinic acid (BCCEP): a new reagent for hemoglobin modification. Artif Cells Blood Substit Immobil Biotechnol 25:511-20

Bertha, C M; Hosmane, S H; Zhang, H et al. (1994) Reagents for bioorganic synthesis. 6. The design and synthesis of two novel polyfunctional organic reagents for biomacromolecular modification. J Biomol Struct Dyn 12:413-37