Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048726-04
Application #
2224788
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1992-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Virginia
Department
Physiology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Otero, A S; Doyle, M B; Hartsough, M T et al. (1999) Wild-type NM23-H1, but not its S120 mutants, suppresses desensitization of muscarinic potassium current. Biochim Biophys Acta 1449:157-68
Otero, A S; Xu, L; Ni, Y et al. (1998) Receptor-independent activation of atrial muscarinic potassium channels in the absence of nucleotides. J Biol Chem 273:28868-72
Otero, A S (1997) Copurification of vimentin, energy metabolism enzymes, and a MER5 homolog with nucleoside diphosphate kinase. Identification of tissue-specific interactions. J Biol Chem 272:14690-4
Yi, X B; Seitzer, N M; de S Otero, A (1996) Neutralizing antibodies to nucleoside diphosphate kinase inhibit the enzyme in vitro and in vivo: evidence for two distinct mechanisms of activation of atrial currents by ATPgammaS. Biochim Biophys Acta 1310:334-42
Xu, L; Murphy, J; Otero, A S (1996) Participation of nucleoside-diphosphate kinase in muscarinic K+ channel activation does not involve GTP formation. J Biol Chem 271:21120-5
Lee, M S; Sawyer, S; Arnush, M et al. (1996) Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice. Transplantation 61:1112-5
Lee, M S; Gu, D; Feng, L et al. (1995) Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1. Am J Pathol 147:42-52
Otero, A S; Yi, X B; Gray, M C et al. (1995) Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin. J Biol Chem 270:9695-7
Otero, A de S; Sweitzer, N M (1993) Benzoquinoid tyrosine kinase inhibitors are potent blockers of cardiac muscarinic receptor function. Mol Pharmacol 44:595-604