Posttranscription Regulation of Tropoelastin Expression

Parks, William C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 7R01HL048762-05
• Application #: 2028774
• Study Section: Lung Biology and Pathology Study Section (LBPA)
• Project Start: 1992-09-30
• Project End: 1997-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Barnes-Jewish Hospital
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63110

Publications

Leidenfrost, Jeremy E; Khan, M Faisal; Boc, Kenneth P et al. (2003) A model of primary atherosclerosis and post-angioplasty restenosis in mice. Am J Pathol 163:773-8

Zhang, M; Pierce, R A; Wachi, H et al. (1999) An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor beta1. Mol Cell Biol 19:7314-26

Doyle, G A; Saarialho-Kere, U K; Parks, W C (1997) Distinct mechanisms regulate TIMP-1 expression at different stages of phorbol ester-mediated differentiation of U937 cells. Biochemistry 36:2492-500

Doyle, G A; Pierce, R A; Parks, W C (1997) Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site. J Biol Chem 272:11840-9

Parks, W C (1997) Posttranscriptional regulation of lung elastin production. Am J Respir Cell Mol Biol 17:1-2

Mariani, T J; Roby, J D; Mecham, R P et al. (1996) Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-beta as a mediator of fibrosis. Am J Pathol 148:151-64

Thompson, R W; Parks, W C (1996) Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann N Y Acad Sci 800:157-74

Halpert, I; Sires, U I; Roby, J D et al. (1996) Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A 93:9748-53

Pierce, R A; Mariencheck, W I; Sandefur, S et al. (1995) Glucocorticoids upregulate tropoelastin expression during late stages of fetal lung development. Am J Physiol 268:L491-500

Swee, M H; Parks, W C; Pierce, R A (1995) Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J Biol Chem 270:14899-906