Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049003-05
Application #
2225105
Study Section
Special Emphasis Panel (SRC (MP))
Project Start
1992-08-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Xie, Junxia; Adams, Lynn M; Zhao, Jiying et al. (2002) A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification. J Biol Chem 277:23019-27
Kube, D; Sontich, U; Fletcher, D et al. (2001) Proinflammatory cytokine responses to P. aeruginosa infection in human airway epithelial cell lines. Am J Physiol Lung Cell Mol Physiol 280:L493-502
Kube, D; Adams, L; Perez, A et al. (2001) Terminal sialylation is altered in airway cells with impaired CFTR-mediated chloride transport. Am J Physiol Lung Cell Mol Physiol 280:L482-92
Rajan, S; Cacalano, G; Bryan, R et al. (2000) Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: analysis of the effects of cystic fibrosis transmembrane conductance regulator dysfunction and bacterial virulence factors. Am J Respir Cell Mol Biol 23:304-12
Xie, J; Zhao, J; Davis, P B et al. (2000) Conformation, independent of charge, in the R domain affects cystic fibrosis transmembrane conductance regulator channel openings. Biophys J 78:1293-305
Tasch, J E; Zerhusen, B; Zhao, J et al. (1999) Functional dissection of the R domain of cystic fibrosis transmembrane conductance regulator. FEBS Lett 445:63-8
Bryan, R; Kube, D; Perez, A et al. (1998) Overproduction of the CFTR R domain leads to increased levels of asialoGM1 and increased Pseudomonas aeruginosa binding by epithelial cells. Am J Respir Cell Mol Biol 19:269-77
Ma, J; Zhao, J; Drumm, M L et al. (1997) Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel. J Biol Chem 272:28133-41
Zhao, J; Zerhusen, B; Xie, J et al. (1996) Rectification of cystic fibrosis transmembrane conductance regulator chloride channel mediated by extracellular divalent cations. Biophys J 71:2458-66
Xie, J; Drumm, M L; Zhao, J et al. (1996) Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes. Biophys J 71:3148-56

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