Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049090-03
Application #
2225182
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1994-04-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Henry Ford Health System
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202
Velez, Mauricio; Kohli, Smita; Sabbah, Hani N (2014) Animal models of insulin resistance and heart failure. Heart Fail Rev 19:1-13
Rastogi, Sharad; Sharov, Victor G; Mishra, Sudhish et al. (2008) Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol 295:H2149-55
Maltsev, Victor A; Silverman, Norman; Sabbah, Hani N et al. (2007) Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail 9:219-27
Morita, Hideaki; Khanal, Sanjaya; Rastogi, Sharad et al. (2006) Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Am J Physiol Heart Circ Physiol 290:H2522-7
Mishra, Sudhish; Sabbah, Hani N; Rastogi, Sharad et al. (2005) Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure. Heart Vessels 20:23-32
Rastogi, Sharad; Gupta, Ramesh C; Mishra, Sudhish et al. (2005) Long-term therapy with the acorn cardiac support device normalizes gene expression of growth factors and gelatinases in dogs with heart failure. J Heart Lung Transplant 24:1619-25
Sharov, Victor G; Kostin, Sawa; Todor, Anastassia et al. (2005) Expression of cytoskeletal, linkage and extracellular proteins in failing dog myocardium. Heart Fail Rev 10:297-303
Sabbah, Hani N (2004) Effects of cardiac support device on reverse remodeling: molecular, biochemical, and structural mechanisms. J Card Fail 10:S207-14
Morita, Hideaki; Suzuki, George; Haddad, Walid et al. (2004) Long-term effects of non-excitatory cardiac contractility modulation electric signals on the progression of heart failure in dogs. Eur J Heart Fail 6:145-50
Zicha, Stephen; Maltsev, Victor A; Nattel, Stanley et al. (2004) Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure. J Mol Cell Cardiol 37:91-100

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