Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049103-04
Application #
2225205
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1993-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Gradinaru, Irina; Babaeva, Ekaterina; Schwinn, Debra A et al. (2015) Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway. PLoS One 10:e0142787
Kleine-Brueggeney, Maren; Gradinaru, Irina; Babaeva, Ekaterina et al. (2014) Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways. Cell Signal 26:1985-97
Schwinn, Debra A; Mackensen, G Burkhard; Brown, Emery N (2012) Understanding the TXA seizure connection. J Clin Invest 122:4339-41
Schwinn, Debra; Kleine-Brueggeney, Maren; Oganesian, Anush (2012) Genomic Medicine: Why Do ""Similar"" Patients Have Different Outcomes? Rev Course Lect 2012:30-34
von Homeyer, Peter; Schwinn, Debra A (2011) Pharmacogenomics of ?-adrenergic receptor physiology and response to ?-blockade. Anesth Analg 113:1305-18
Schwinn, D A (2011) Genetics and patient outcome after cardiac surgery: unravelling translational findings. Br J Anaesth 107:839-41
Lei, Beilei; Morris, Daniel P; Smith, Michael P et al. (2009) Lipid rafts constrain basal alpha(1A)-adrenergic receptor signaling by maintaining receptor in an inactive conformation. Cell Signal 21:1532-9
Stafford-Smith, Mark; Bartz, Raquel; Wilson, Katrina et al. (2007) Alpha-adrenergic mRNA subtype expression in the human nasal turbinate. Can J Anaesth 54:549-55
Schwinn, Debra A; Afshari, Natalie A (2006) alpha(1)-Adrenergic receptor antagonists and the iris: new mechanistic insights into floppy iris syndrome. Surv Ophthalmol 51:501-12
Schwinn, Debra A; Afshari, Natalie A (2005) Alpha1-adrenergic antagonists and floppy iris syndrome: tip of the iceberg? Ophthalmology 112:2059-60

Showing the most recent 10 out of 28 publications