Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049517-03
Application #
2225588
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1994-05-01
Project End
1997-10-31
Budget Start
1996-05-01
Budget End
1997-10-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Blank, M; Eldor, A; Tavor, S et al. (1999) A mouse model for heparin-induced thrombocytopenia. Semin Hematol 36:12-6
Blank, M; Cines, D B; Arepally, G et al. (1997) Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin. Clin Exp Immunol 108:333-9
Zhang, L; Strickland, D K; Cines, D B et al. (1997) Regulation of single chain urokinase binding, internalization, and degradation by a plasminogen activator inhibitor 1-derived peptide. J Biol Chem 272:27053-7
Higazi, A A; Mazar, A; Wang, J et al. (1997) Soluble human urokinase receptor is composed of two active units. J Biol Chem 272:5348-53
McCrae, K R; Cines, D B (1997) Thrombotic microangiopathy during pregnancy. Semin Hematol 34:148-58
Higazi, A A; Lavi, E; Bdeir, K et al. (1997) Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells. Blood 89:4290-8
Shlansky-Goldberg, R D; Cines, D B; Sehgal, C M (1996) Catheter-delivered ultrasound potentiates in vitro thrombolysis. J Vasc Interv Radiol 7:313-20
Higazi, A A; Ganz, T; Kariko, K et al. (1996) Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells. J Biol Chem 271:17650-5
Higazi, A A; Upson, R H; Cohen, R L et al. (1996) Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood 88:542-51
Cines, D B; McCrae, K R (1995) The antiphospholipid-protein syndrome. J Clin Immunol 15:86S-100S

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