Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049542-04
Application #
2225615
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Pathology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Thogersen, Ida B; Hammes, Stephen R; Rubenstein, David S et al. (2002) New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. Biochim Biophys Acta 1598:131-9
Berggard, T; Cohen, A; Persson, P et al. (1999) Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound. Protein Sci 8:2611-20
Fishman, D A; Kearns, A; Larsh, S et al. (1999) Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment. Biochem J 341 ( Pt 3):765-9
Enghild, J J; Thogersen, I B; Oury, T D et al. (1999) The heparin-binding domain of extracellular superoxide dismutase is proteolytically processed intracellularly during biosynthesis. J Biol Chem 274:14818-22
Enghild, J J; Thogersen, I B; Cheng, F et al. (1999) Organization of the inter-alpha-inhibitor heavy chains on the chondroitin sulfate originating from Ser(10) of bikunin: posttranslational modification of IalphaI-derived bikunin. Biochemistry 38:11804-13
Olsen, E H; Rahbek-Nielsen, H; Thogersen, I B et al. (1998) Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. Biochemistry 37:408-16
Valnickova, Z; Enghild, J J (1998) Human procarboxypeptidase U, or thrombin-activable fibrinolysis inhibitor, is a substrate for transglutaminases. Evidence for transglutaminase-catalyzed cross-linking to fibrin. J Biol Chem 273:27220-4
Christensen, S; Valnickova, Z; Thogersen, I B et al. (1997) Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. Biochem J 323 ( Pt 3):847-52
Klintworth, G K; Valnickova, Z; Kielar, R A et al. (1997) Familial subepithelial corneal amyloidosis--a lactoferrin-related amyloidosis. Invest Ophthalmol Vis Sci 38:2756-63
Folz, R J; Guan, J; Seldin, M F et al. (1997) Mouse extracellular superoxide dismutase: primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization. Am J Respir Cell Mol Biol 17:393-403

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