Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049930-03
Application #
2028875
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1996-09-17
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Jongen-Lavrencic, M; Salesse, S; Delwel, R et al. (2005) BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells. Leukemia 19:373-80
Melikova, Sofya; Dylla, Scott J; Verfaillie, Catherine M (2004) Phosphatidylinositol-3-kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to beta1-integrins in human CD34+ cells. Exp Hematol 32:1051-6
Salesse, S; Dylla, S J; Verfaillie, C M (2004) p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells. Leukemia 18:727-33
Dylla, Scott J; Deyle, David R; Theunissen, Koen et al. (2004) Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. Exp Hematol 32:365-74
Salesse, Stephanie; Verfaillie, Catherine M (2003) BCR/ABL-mediated increased expression of multiple known and novel genes that may contribute to the pathogenesis of chronic myelogenous leukemia. Mol Cancer Ther 2:173-82
Punzel, Michael; Gupta, Pankaj; Verfaillie, Catherine M (2002) The microenvironment of AFT024 cells maintains primitive human hematopoiesis by counteracting contact mediated inhibition of proliferation. Cell Commun Adhes 9:149-59
Prosper, F; Verfaillie, C M (2001) Regulation of hematopoiesis through adhesion receptors. J Leukoc Biol 69:307-16
Zhao, R C; Jiang, Y; Verfaillie, C M (2001) A model of human p210(bcr/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR/ABL-containing retroviral vector. Blood 97:2406-12
Jiang, Y; Prosper, F; Verfaillie, C M (2000) Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors. Blood 95:846-54
Jiang, Y; Zhao, R C; Verfaillie, C M (2000) Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity. Proc Natl Acad Sci U S A 97:10538-43

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