Plasminogen Activation - Structure-Activity Analysis

Reich, Edward

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL050320-03
• Application #: 2226488
• Study Section: Biochemistry Study Section (BIO)
• Project Start: 1993-12-01
• Project End: 1997-08-31
• Budget Start: 1995-12-01
• Budget End: 1997-08-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: State University New York Stony Brook
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 804878247
• City: Stony Brook
• State: NY
• Country: United States
• Zip Code: 11794

Publications

Peisach, E; Wang, J; de los Santos, T et al. (1999) Crystal structure of the proenzyme domain of plasminogen. Biochemistry 38:11180-8

de los Santos, T; Wang, J; Reich, E (1997) Structure and function of microplasminogen: reconstitution of microplasminogen and microplasmin from isolated fragments. Ciba Found Symp 212:66-76; discussion 76-83

Wang, J; Brdar, B; Reich, E (1995) Structure and function of microplasminogen: I. Methionine shuffling, chemical proteolysis, and proenzyme activation. Protein Sci 4:1758-67

Wang, J; Reich, E (1995) Structure and function of microplasminogen: II. Determinants of activation by urokinase and by the bacterial activator streptokinase. Protein Sci 4:1768-79