Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050656-03
Application #
2226898
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1994-07-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Nuriel, Tal; Deeb, Ruba S; Hajjar, David P et al. (2008) Protein 3-nitrotyrosine in complex biological samples: quantification by high-pressure liquid chromatography/electrochemical detection and emergence of proteomic approaches for unbiased identification of modification sites. Methods Enzymol 441:1-17
Deeb, Ruba S; Hao, Gang; Gross, Steven S et al. (2006) Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite. J Lipid Res 47:898-911
Hattori, Yoshiyuki; Kasai, Kikuo; Gross, Steven S (2004) NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovasc Res 63:31-40
Kolinsky, Monica A; Gross, Steven S (2004) The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein. J Biol Chem 279:40677-82
Brodsky, Sergey V; Gealekman, Olga; Chen, Jun et al. (2004) Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res 94:377-84
Hao, Gang; Xie, Linjun; Gross, Steven S (2004) Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo. J Biol Chem 279:36192-200
Lane, Paul; Gross, Steven S (2002) Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli. J Biol Chem 277:19087-94
Weissman, Ben A; Jones, Caroline L; Liu, Qing et al. (2002) Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca(2+)-dependent [125I]Calmodulin binding. Eur J Pharmacol 435:9-18
Brodsky, S V; Morrishow, A M; Dharia, N et al. (2001) Glucose scavenging of nitric oxide. Am J Physiol Renal Physiol 280:F480-6
Xie, L; Hattori, Y; Tume, N et al. (2000) The preferred source of arginine for high-output nitric oxide synthesis in blood vessels. Semin Perinatol 24:42-5

Showing the most recent 10 out of 24 publications