Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050692-05
Application #
2226947
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1993-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
St. Elizabeth's Medical Center of Boston
Department
Type
DUNS #
073797292
City
Boston
State
MA
Country
United States
Zip Code
01235
Skaletz-Rorowski, Adriane; Lutchman, Mohini; Kureishi, Yasuko et al. (2003) HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells. Cardiovasc Res 57:253-64
Kim, Hyo-Soo; Skurk, Carsten; Thomas, Shane R et al. (2002) Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem 277:41888-96
Shiojima, Ichiro; Walsh, Kenneth (2002) Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90:1243-50
Shiojima, Ichiro; Yefremashvili, Mikkael; Luo, Zhengyu et al. (2002) Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 277:37670-7
Suhara, Toshimitsu; Kim, Hyo-Soo; Kirshenbaum, Lorrie A et al. (2002) Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol Cell Biol 22:680-91
Takahashi, Akihiro; Kureishi, Yasuko; Yang, Jiang et al. (2002) Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth. Mol Cell Biol 22:4803-14
Sata, M; Luo, Z; Walsh, K (2001) Fas ligand overexpression on allograft endothelium inhibits inflammatory cell infiltration and transplant-associated intimal hyperplasia. J Immunol 166:6964-71
Querfurth, H W; Suhara, T; Rosen, K M et al. (2001) Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy. Mol Cell Neurosci 17:793-810
Gratton, J P; Morales-Ruiz, M; Kureishi, Y et al. (2001) Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 276:30359-65
Kureishi, Y; Luo, Z; Shiojima, I et al. (2000) The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6:1004-10

Showing the most recent 10 out of 55 publications