Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050775-03
Application #
2227063
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1994-07-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Kemper, Martin F; Stirone, Chris; Krause, Diana N et al. (2014) Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection. Eur J Pharmacol 723:322-9
Kemper, Martin F; Zhao, Yuanzi; Duckles, Sue P et al. (2013) Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms. J Cereb Blood Flow Metab 33:122-8
Guo, Jiabin; Duckles, Sue P; Weiss, John H et al. (2012) 17?-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med 52:2151-60
Krause, D N; Duckles, S P; Gonzales, R J (2011) Local oestrogenic/androgenic balance in the cerebral vasculature. Acta Physiol (Oxf) 203:181-6
Duckles, S P; Krause, D N (2011) Mechanisms of cerebrovascular protection: oestrogen, inflammation and mitochondria. Acta Physiol (Oxf) 203:149-54
Duckles, Sue P; Miller, Virginia M (2010) Hormonal modulation of endothelial NO production. Pflugers Arch 459:841-51
Guo, Jiabin; Krause, Diana N; Horne, James et al. (2010) Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab 30:545-54
Gonzales, Rayna J; Duckles, Sue P; Krause, Diana N (2009) Dihydrotestosterone stimulates cerebrovascular inflammation through NFkappaB, modulating contractile function. J Cereb Blood Flow Metab 29:244-53
Razmara, Ali; Sunday, Lorraine; Stirone, Chris et al. (2008) Mitochondrial effects of estrogen are mediated by estrogen receptor alpha in brain endothelial cells. J Pharmacol Exp Ther 325:782-90
Miller, Virginia M; Duckles, Sue P (2008) Vascular actions of estrogens: functional implications. Pharmacol Rev 60:210-41

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